MyBioSource.com's IkappaB-alpha (Ab-32/36) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. The IkappaB-alpha (Ab-32/36) Antibody was generated using I kappa B alpha, IKB alpha, IkBa, NFKBI, and NFKBIA as the antigen and it reacts with Human.
Description
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44.Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15.Nair A, et al. (2003) Oncogene; 22(1): 50-8.Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53.Schubert SY, et al. (2002)FASEB J; 16(14): 193